TOKYO and RAHWAY, NJ, Oct. 29, 2025 - (JCN Newswire via SeaPRwire.com) - Eisai (Headquarters: Tokyo, CEO: Haruo Naito) and Merck & Co., Inc., Rahway, NJ, USA (known as MSD outside of the United States and Canada) today announced results from that Phase 3 LEAP-012 trial evaluating LENVIMA® (lenvatinib), the orally available multiple receptor tyrosine kinase inhibitor (TKI)discovered by Eisai, plus KEYTRUDA® (pembrolizumab), the anti-PD-1 therapy from Merck & Co.,Inc., Rahway, NJ, USA, in combination with transarterial chemoembolization (TACE) for the treatment of patients with unresectable, non-metastatic hepatocellular carcinoma (HCC).At a pre-specified interim analysis, LENVIMA plus KEYTRUDA in combination with TACE did not achieve statistical significance for overall survival (OS), one of the study’s primary endpoints, compared to TACE alone. The likelihood of reaching the protocol-specified threshold for statistical significance for OS at a future analysis was evaluated by Eisai and Merck & Co.,Inc., Rahway, NJ, USA and considered to be low. On this basis, the study will be closed, and the companies are informing investigators of this decision.The safety profile of the LENVIMA plus KEYTRUDA-based regimen was consistent with that observed in previously reported studies evaluating the combination and in earlier analyses of LEAP-012. Further analysis of the data is ongoing. Eisai and Merck & Co., Inc., Rahway, NJ, USA will work with investigators to share the results with the scientific community.As reported previously, LENVIMA plus KEYTRUDA in combination with TACE met the study’s other primary endpoint of progression-free survival (PFS) and demonstrated a statistically significant and clinically meaningful improvement compared to TACE alone. Data from this first interim analysis, which served as the final analysis for the endpoint of PFS, were presented at the European Society for Medical Oncology (ESMO) Congress 2024 and published in The Lancet. With additional follow-up at subsequent analyses, PFS remained consistent.“Although the progression-free survival results from this study are encouraging, unfortunately, the addition of KEYTRUDA plus LENVIMA to TACE did not show the overall survival benefit we hoped,” said Dr. Gregory Lubiniecki, Vice President, Global Clinical Development, MSD Research Laboratories. “We are grateful to the patients and investigators for their important contributions to this study, and our commitment is unwavering as we pursue new therapeutic options for people living with hepatocellular carcinoma, an aggressive and challenging-to-treat cancer.”“The overall survival findings from LEAP-012, along with the previously reported improvement in progression-free survival, provide important insights for treating unresectable, non-metastatic hepatocellular carcinoma,” said Dr. Corina Dutcus, Senior Vice President, Oncology Global Clinical Development Lead at Eisai. “For years, TACE has been a standard of care for these patients, yet many experience disease progression within twelve months. With LEAP-012, we sought to make a meaningful difference for this patient population. LENVIMA continues to play an important role as a monotherapy treatment option for patients with unresectable HCC, and as a company with a deep heritage in liver cancer research, Eisai remains committed to advancing the science.”In July 2025, LENVIMA plus KEYTRUDA in combination with TACE was approved in China to treat unresectable non-metastatic HCC. The LENVIMA plus KEYTRUDA combination is approved in the U.S., the European Union (EU), Japan and other countries for the treatment of advanced renal cell carcinoma (RCC) and certain types of advanced endometrial carcinoma. Results from the LEAP-012 trial do not affect the current approved indications for the LENVIMA plus KEYTRUDA combination, including the approval of LENVIMA plus KEYTRUDA in combination with TACE in China to treat unresectable non-metastatic HCC.LENVIMA monotherapy is approved for the treatment of patients with unresectable HCC in more than 80 countries and regions, including in the U.S., the EU, China and Japan.KEYTRUDA is approved as a monotherapy for the treatment of patients with HCC secondary to hepatitis B who have received prior systemic therapy other than a PD-1/PD-L1-containing regimen in the U.S. and as a monotherapy for the treatment of patients with HCC who have been previously treated with sorafenib or oxaliplatin-containing chemotherapy in China.For more details, please visit: https://www.eisai.com/news/2025/pdf/enews202576pdf.pdf Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com

HIROSHIMA, Japan, October 29, 2025 - (JCN Newswire via SeaPRwire.com) - During the press conference at the Japan Mobility Show 2025(*1) today, Mazda Motor Corporation (Mazda) unveiled two vision models, the MAZDA VISION X-COUPE and the MAZDA VISION X-COMPACT (‘X’ pronounced as ‘cross’ ), both embodying the Company’s theme for this year's exhibition: “The Joy of Driving Fuels a Sustainable Tomorrow” for 2035.The MAZDA VISION X-COUPE is a crossover coupe that embodies the further evolution of ‘KODO-Soul of Motion’ design language. It is powered by a plug-in hybrid system integrating a two-rotor rotary turbo engine with a motor and battery. With a maximum output of 510 PS, the vehicle offers a driving range of 160 km in motor-only mode and up to 800 km when operating in combination with the engine. Furthermore, by combining carbon-neutral fuel derived from microalgae with Mazda’s proprietary CO2 capture technology, “Mazda Mobile Carbon Capture,” the vehicle contributes to reducing atmospheric CO2 the more it is driven.MAZDA VISION X-COUPEThe MAZDA VISION X-COMPACT is a model designed to deepen the bond between people and cars through the fusion of a human sensory digital model and empathetic AI. Acting like a close companion, it is capable of engaging in natural conversation and suggesting destinations, helping expand the driver’s world. This represents Mazda’s vision for the future of smart mobility, where vehicles and people form an emotional connection, much like a friend.MAZDA VISION X-COMPACTFurthermore, the All-New MAZDA CX-5 (European specification) (*2) , is on display to the general public for the first time ever. Featuring a spacious interior, refined KODO design, and enhanced Jinba-ittai (oneness between driver and car) driving dynamics, this model represents the evolution of a best-selling vehicle that has sold over 4.5 million units (*3) across more than 100 countries and regions. Designed with the new electronic platform “MAZDA E/E ARCHITECTURE+”, this latest model aims to offer an evolved driving experience.Masahiro Moro, Representative Director, President and CEO of Mazda, stated: “The phrase, ‘The joy of driving fuels a sustainable tomorrow,’ expresses not only Mazda’s fundamental spirit, but also the core of its future challenges. Under the shared global mission of achieving carbon neutrality, Mazda believes that the joy of driving can be a force for positive change for society and the planet. We remain committed to fulfilling the desire of those who love cars and wish to continue driving forever.”Mazda will continue to evolve the ‘Joy of Driving’ based on the value of ‘Radically Human,’ and will aim to deliver the ‘Joy of Living’ by creating exciting mobility experiences in our customers' daily lives.Overview of the MAZDA VISION X-COUPE and MAZDA VISION X-COMPACTModelMAZDA VISION X-COUPEMAZDA VISION X-COMPACTOverall Length5,050 mm3,825 mmOverall Width1,995 mm1,795 mmOverall Height1,480 mm1,470 mmWheelbase3,080 mm2,515 mm*1 Hosted by the Japan Automobile Manufacturers Association, Inc.Press Day: Wednesday, October 29, 8:00-18:00, and Thursday, October 30, 8:00-13:00.Public Day: starting Friday, October 31 until Sunday, November 9.*2 For the new MAZDA CX-5, please see the news release at the following URL.https://newsroom.mazda.com/en/publicity/release/2025/202507/250710a.html*3 Mazda's best-selling model in its current lineup from 2018 to 2024 Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com

HIROSHIMA, Japan, October 29, 2025 - (JCN Newswire via SeaPRwire.com) - Mazda Motor Corporation (Mazda) announced today that it will gradually roll out a new version of its brand symbol, embodying its unwavering belief and enduring commitment to shaping the future. This brand symbol will also be featured at the Mazda booth at the Japan Mobility Show 2025, a place to showcase the future of the Mazda brand to the world, delivering Mazda's new brand expression to visitors. Mazda booth at Japan Mobility Show 2025 featuring the new version of the brand symbolThe new version of Mazda’s brand symbol inherits the spirit of its symbol introduced in June 1997, representing the letter 'M' with the evocation of soaring wings. This embodies the Company’s commitment to continuous self-reform and dynamic, unceasing growth. It demonstrates the evolution of the brand toward the next generation.The sleek and bold form enhances visibility, particularly in digital environments, resulting in a more refined design. The new version of the wordmark, launched alongside it, adopts a modern style. The new version of the brand symbol and wordmark are now being adopted on the Mazda corporate website starting today.New version of the brand symbol in the digital areaThe new version of the brand symbol and the current brand symbol will be applied optimally according to location and media characteristics to enhance global brand recognition.Mazda will continue to pursue the "Joy of Driving" under its core value of “Radically Human,” and aim to deliver the "Joy of Living" by creating moving mobility experiences in the daily lives of its customers.*Definition of Each Mark Reference- Mazda corporate website featuring the new version of the brand mark:https://www.mazda.com/en/- Mazda brand mark history page:https://www.mazda.com/en/about/history/mark- Japan Mobility Show 2025 Mazda Exhibit Release:https://newsroom.mazda.com/en/publicity/release/2025/202510/251014a.html Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com

TOKYO, Japan, October 29, 2025 - (JCN Newswire via SeaPRwire.com) - NEC Corporation (NEC; TSE: 6701) and the Cambodian Mine Action Center (CMAC, *1), the national institution responsible for landmine clearance activities in Cambodia, with assistance from JICA (*2), conducted a proof-of-concept using AI to predict landmine-contaminated areas. This initiative aims to contribute to rapid and efficient clearance operations to eliminate landmine casualties. The proof-of-concept achieved highly accurate predictions, with a match rate exceeding 90% against actual landmine locations.This initiative also received recognition through "The GICHD Innovation Award 2025," hosted by the Geneva International Centre for Humanitarian Demining (GICHD, *3), which honors outstanding technologies contributing to progress in demining activities. The award was presented at a ceremony held in Luxembourg on Tuesday, October 28. Removing landmines in an area Award Ceremonypredicted by AI in Cambodia ©GICHD/PANCAKE! PhotographieThe use of landmines remains a humanitarian issue worldwide, particularly hindering community and economic development for extended periods in post-conflict nations. It is estimated that approximately 100 million people face the threat of landmines, with one person losing their life to a landmine every 90 minutes (*4).In Cambodia, civil war spanning the 1970s and 1990s led to the widespread burial of landmines across the country. Despite years of dedicated clearance efforts, remnant landmines persist in some areas today. These landmines prevent the use of land for farming and residential purposes, posing serious obstacles to recovery and development.The Cambodian government, based on the Ottawa Treaty (Convention on the Prohibition of the Use, Stockpiling, Production and Transfer of Anti-Personnel Mines and on Their Destruction) signed in 1997, has set a target of completing landmine clearance within Cambodia by 2030. To achieve this, it is expected that advanced technologies such as AI will be utilized to reduce survey time.This demonstration targeted approximately 1 million square meters of Cambodia's landmine fields. NEC's AI analyzed information based on data that included CMAC's records of detected landmine locations, resident-provided information, and open data such as river/mountainous terrain locations and factory/critical building sites. It then accurately predicted areas with a high probability of containing buried landmines.Traditionally, identifying potential landmine-infested areas required extensive, unorganized data and significant manpower over long periods. By leveraging AI, this process can now be performed quickly with fewer personnel, demonstrating the potential to support swift and efficient landmine clearance.Going forward, NEC will continue striving to further improve AI's accuracy. Working with CMAC, with assistance from JICA, and strengthening collaboration with the Japanese government, NEC will accelerate efforts toward achieving Cambodia's goal of completing landmine clearance by 2030. Furthermore, NEC aims to contribute to other landmine-affected countries using this technology in the future.(*1) Cambodian Mine Action Center (CMAC)Location: Phnom Penh, Cambodia; Director: Heng Rathana(*2) Japan International Cooperation Agency(*3) Geneva International Center for Humanitarian Demining (GICHD)Location: Geneva, Switzerland; Director: Stefano Toscan(*4) Source: the-monitor.org/reports/landmine-monitorLandmine Monitor 2024 Full PaperAbout NEC CorporationNEC Corporation has established itself as a leader in the integration of IT and network technologies while promoting the brand statement of “Orchestrating a brighter world.” NEC enables businesses and communities to adapt to rapid changes taking place in both society and the market as it provides for the social values of safety, security, fairness and efficiency to promote a more sustainable world where everyone has the chance to reach their full potential. For more information, visit NEC at https://www.nec.com. Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com

TOKYO, Japan, October 29, 2025 - (JCN Newswire via SeaPRwire.com) - Honda Motor Co., Ltd. Director, President and Representative, Toshihiro Mibe today held a press conference at the Japan Mobility Show 2025.Following is an overview of his remarks, including support information:Honda exhibits mobility products and technologies for land, sea, skies and outer spaceWorld premiere of prototype of Honda 0 α, new SUV model for the Honda 0 SeriesWorld premiere of EV OUTLIER Concept, new vision for motorcycles beyond 2030World premiere of Super-ONE Prototype, compact EV will create excitement and uplifting feeling in people’s daily livesHonda exhibits sustainable rocket used for launch and landing test in June 2025About Japan Mobility Show 2025Honda is a company that has always put its heart and soul into realizing its own dreams. This year, Honda is exhibiting a wide variety of mobility products and technologies for land, sea and skies, and also for outer space. Honda would like visitors to ride and touch these items on display to feel the excitement for the future envisioned by Honda. Next-generation EVs for electrified eraHonda is working toward an ambitious goal of achieving carbon neutrality for all of its products and corporate activities by 2050. Although the market environment surrounding electrification continues to be uncertain, Honda believes that, in the long run, the shift toward EVs will continue. Therefore, Honda is steadily preparing to deliver attractive EV models in the upcoming electrified era.Honda 0 Series, next-generation EVs of Honda Honda 0 Series is the next-generation series of EVs that Honda will offer by going back to the starting point of Honda as an automaker and creating new EVs from “zero” based on original ideas. With the unique development approach of “Thin, Light, and Wise.”, Honda 0 Series will defy existing conventions that EVs are “thick and heavy” and create completely new value. The prototype of the Honda 0 Saloon, the flagship model of Honda 0 Series, is built on a low-floor platform dedicated to EVs and features both sporty styling with a low vehicle height and a much more spacious cabin space than people would expect from the exterior design.The prototype of the Honda 0 SUV, a mid-size SUV which is the first Honda 0 Series model scheduled for market launch, features a spacious cabin with a clear and unrestricted field of view and great flexibility, realized by applying the unique “Thin, Light, and Wise.” development approach to an SUV to further increase the interior space. Honda 0 Saloon Prototype Honda 0 SUV PrototypeThese models feature ASIMO OS, the original Honda vehicle OS, which will enable continuous advancement of various functions even after the purchase of the vehicle. So, the more the customer uses it, the more personalized the car becomes to offer “ultra-personal optimization” of the customer’s mobility experience. Honda 0 α, a new SUV for Honda 0 SeriesHonda is presenting the world premiere of the prototype of the Honda 0 α (alpha), a new SUV model for the Honda 0 Series. Featuring a sleek and sophisticated design unique to Honda 0 Series and original proportions that express the dynamic nature of SUVs, the Honda 0 α will blend beautifully with both urban and natural environments, supporting people’s lives in every situation.By applying packaging design based on the “Thin” approach, styling with a low vehicle height was achieved without compromising ground clearance, creating a thin cabin that still offers a spacious and comfortable space for occupants.Honda is planning to begin global sales of the production model of Honda 0 α, mainly in Japan and India, in 2027. With this “gateway model” to the Honda 0 Series, Honda will strive to offer new value to a greater number of customers around the world. In Japan, three Honda 0 Series models — Honda 0 Saloon, Honda 0 SUV, and Honda 0 α — will go on sale before the end of the fiscal year ending March 31, 2028. Honda 0 α PrototypeAcura RSX Prototype, a next-generation EV model for Acura brandHonda is also presenting the Japan premiere of the Acura RSX Prototype, a next-generation EV model for the Acura brand.The Acura RSX Prototype is the first model to adopt the next-generation EV platform developed independently by Honda. It also features ASIMO OS, the original Honda vehicle OS, which will enable the vehicle to learn the preferences and driving patterns of each customer and realize “ultra-personal optimization” of the mobility experience.Acura RSX Prototype *The model on display will feature a different color.EV OUTLIER Concept, a new electric motorcycle model that proposes a new vision for motorcycles beyond 2030Honda is presenting the world premiere of the EV OUTLIER Concept. Not just an extension of existing motorcycles, this concept model proposes a new vision for motorcycles beyond 2030.Taking advantage of the high degree of freedom of the layout unique to electric motorcycles, the EV OUTLIER Concept features in-wheel motors on both the front and rear wheels, achieving dynamic and low-proportion styling. Through electrification, Honda will continue to create unprecedented value with its motorcycles as well. EV OUTLIER ConceptThe “joy of driving,” the enduring philosophy of HondaWhile preparing for the upcoming electrified era, the pursuit of the “joy of driving” unique to Honda – the sense of oneness the driver feels with the vehicle – will never change regardless of the times or type of powertrain. Honda is offering a wide range of products that enable its customers to experience this “joy of driving,” whether they are EV or hybrid models.Super-ONE Prototype, a compact EV that creates excitement and an uplifting feeling in people’s daily livesHonda is presenting the world premiere of the Super-ONE Prototype, a compact EV filled with the playful mind of Honda, which will create new excitement and an uplifting feeling in people’s daily lives.Leveraging the lightweight platform advanced for N Series models, the Super-ONE Prototype realizes sporty and nimble driving. In addition, its wide stance with extended tread, realized by prominently flared blister fenders, enables a stable and dynamic driving experience.Moreover, it features “Boost Mode” developed exclusively for this model. As the power output increases, engine sound fills the cabin in sync with the feeling of shifting gears, as if driving an engine-powered vehicle. The Super-ONE offers an uplifting driving experience by combining outstanding acceleration unique to EVs and the fun of driving engine-powered vehicles.Starting in 2026, the Super-ONE will be launched first in Japan, followed by other markets with strong demand for compact EVs, such as various Asian countries and the U.K. Super-ONE PrototypePrelude, a specialty sports model embodying the unrelenting Honda sports mindsetHonda is also exhibiting the new Prelude, a specialty sports model Honda developed by fully applying an engine and technologies that Honda has perfected over many years, to carry forward the “joy of driving” into the full-fledged electrified era. The development of the new Prelude began with a strong desire to create a model that represents the Honda of today, and it was perfected as a model Honda recommends with absolute confidence.New PreludeCreating new value through enhanced application of intelligent technologiesHonda is striving to continue offering new value through a variety of mobility products and services. The key element in realizing such new value is the enhanced application of intelligent technologies. As one of the core intelligent technologies, Honda is strengthening the development of its next-generation ADAS.When the driver sets a destination on the navigation system, the ADAS will enable the vehicle to take charge of driving, such as controlling the accelerator and steering wheel, to achieve a comfortable ride to the destination. This function will give the driver peace of mind as if an experienced driver is in charge of driving operations, which will provide confidence even on unfamiliar roads and significantly reduce the burden of driving.Honda is currently testing its next-generation ADAS on public roads in the U.S., making steady progress in development. Starting around 2027, Honda will apply this technology not only to its EVs, but also to hybrid models to offer new value to the greater number of customers through their experience of expanding the freedom of mobility. A wide variety of mobility products and technologies for land, sea, skies and outer spaceIn addition to motorcycle and automobile products and technologies, as a comprehensive mobility company, Honda has been offering a wide range of mobility products for land, sea, and skies. Including power products such as tillers and outboard motors, as well as the HondaJet, a light business jet, Honda is offering a wide variety of mobility products that will help people expand their life’s potential.Including next-generation mobility products such as micromobility vehicles that will make last-mile mobility more convenient, and eVTOLs that will make mobility in the skies more accessible for more people, Honda will continue taking on challenges to spread the “joy and freedom of mobility” to more people.And now, Honda has expanded its challenges to outer space.Outer space - Taking on a new frontier with sustainable rocketsThe actual rocket Honda used for the launch and landing test conducted in Hokkaido, Japan in June 2025 is also on display at the Honda booth. Honda is striving to develop environmentally-responsible “sustainable rockets” which will enable the reuse of the rocket as well as the use of renewable fuel. Test being conducted in Hokkaido, Japan Actual launch and landing test in June 2025(Photo taken in May, 2025)In the testing in June, precise control was applied on the rocket’s attitude and speed from takeoff to landing, to achieve the exact rocket behaviors planned. This success was achieved by the collective strength of Honda technologies, including control technologies amassed through automated driving and aircraft development, as well as the passion of each and every Honda associate “at the spot” who kept taking on challenges with determination.Honda rocket research and development has just taken its first step. No matter what difficulties lie ahead, Honda will overcome them by continuing to take on challenges without giving up. ClosingIn line with the Honda Global Brand Slogan — The Power of Dreams — How we move you. — each and every Honda associate with dreams and passion will continue taking on new challenges to carve out the future of Honda and create value only Honda can create.The Honda booth is introducing the future Honda aims to realize through its wide variety of mobility products and technologies, enabling visitors to feel excitement for the future. For more details, please visit: https://global.honda/en/newsroom/news/2025/c251029eng.html Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com

TOKYO, Japan, October 29, 2025 - (JCN Newswire via SeaPRwire.com) - Honda Motor Co., Ltd. today presented the world premiere of the prototype of Honda 0 α (alpha) next-generation EV, at the Japan Mobility Show 2025. This prototype model will be on display at the Honda booth throughout the duration of the show (Press days: Oct. 29-30, Public days: Oct. 31-Nov. 9, 2025).Prototype of Honda 0 αThe Honda 0 α is being developed as an SUV that will blend beautifully with both urban and natural environments, supporting people’s lives in every situation. Following the Honda 0 Saloon and the Honda 0 SUV, introduced at CES 2025 in January of this year, the Honda 0 α will be added to the lineup as a “gateway model” for the world of Honda 0 Series, featuring a refined design and a spacious cabin that offers outstanding occupant comfort.Equipped with technologies that embody the Honda 0 Series development approach — “Thin, Light, and Wise.” — the production model of the Honda 0 α is scheduled to go on sales globally, mainly in Japan and India, starting in 2027. Packaging and Exterior DesignBy applying a packaging design based on the “Thin” approach, the styling with a low vehicle height was achieved without compromising ground clearance, creating a thin cabin that still offers a spacious and comfortable space for occupants. The wide stance is expressing stability and dynamic characteristics unique to SUVs.The exterior design features both a sleek and sophisticated body design unique to Honda 0 Series and the original proportion of an SUV. There are screen areas in both the front and rear ends of the vehicle. At the front, components that are conventionally separated — such as the headlights, charging lid and illuminated emblem — are integrated into the screen area. At the rear, the U-shaped lighting that combines the tail lamps, backup lamps and turn signal lamps, accentuates the contour of the rear screen area, achieving a design that is visually and functionally refined. Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com